Novel thrombin-inhibitory proteins from terrestrial leeches

Details Novel thrombin-inhibitory proteins from terrestrial leeches Novel thrombin-inhibitory proteins from terrestrial leeches

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/58 (2006.01) C07K 14/815 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2121601

2121601 9311239 PCTABS00022 Described are new thrombin-inhibiting proteins obtained from terrestrial leeches of the species Haemadipsa and with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-A_ sp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly_ -Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys or an amino-acid sequence obtained by C-terminal shortening the above sequence by one to twelve amino acids. The proteins are suitable for use against illnesses. Also described are the nucleic acids coding for these proteins.

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