Novel thyroid receptor ligands

Details Novel thyroid receptor ligands Novel thyroid receptor ligands

C - Chemistry, Metallurgy

07

C

C07C 59/215 (2006.01) A61K 31/085 (2006.01) A61K 31/33 (2006.01) A61K 51/00 (2006.01) A61P 5/14 (2006.01) A61P 9/06 (2006.01) A61P 17/00 (2006.01) C07D 209/04 (2006.01) C07D 209/12 (2006.01) C07D 213/04 (2006.01) C07D 213/30 (2006.01) C07D 251/12 (2006.01) C07D 251/18 (2006.01) C07D 261/06 (2006.01) C07D 261/08 (2006.01) C07D 263/30 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 413/02 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2481976

This invention relates to novel compounds according to the general formula : which are thyroid receptor ligands, preferably antagonists, partial antagonists or partial agonists and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyro-toxicosis, subclinical hyperthyrodism and liver diseases.

La présente invention concerne de nouveaux composés de formule générale : ( ) qui sont des ligands de récepteurs thyroïdiens, de préférence des antagonistes, des antagonistes partiels ou des agonistes partiels ainsi que des méthodes d'utilisation desdits composés dans le traitement de troubles cardiaques et métaboliques, tels que les arrythmies cardiaques, la thyrotoxicose, l'hyperthyroïdie infraclinique et les maladies hépatiques.

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