A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 14/485 (2006.01) C07K 14/745 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2483910
This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
L'invention concerne de nouveaux anticorps qui se lient au complexe facteur VIIa/facteur tissulaire (FVIIa/TF) avec une affinité supérieure par rapport à la liaison au facteur tissulaire (TF) seul, ne rivalisent pas avec FVII et FX dans la liaison à TF, et inhibent l'activation de FX. Lesdits anticorps se lient au site de lésion et empêchent le déclenchement d'une thrombose. Ces anticorps peuvent servir à traiter diverses affections thrombotiques incluant notamment, mais pas exclusivement, la thrombose veineuse profonde, la coagulation intravasculaire disséminée et le syndrome coronaire aigu.
Light David
Mclean Kirk
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
Schering Aktiengesellschaft
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