C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 38/36 (2006.01) A61K 48/00 (2006.01) C07K 14/485 (2006.01) C07K 14/745 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2483909
This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM ) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser/Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
L'invention concerne de nouvelles protéines de fusion qui sont constituées d'une protéine de ciblage se liant au facteur tissulaire (TF), qui est liée de manière opérationnelle au domaine EGF456 de la thrombomoduline (TM), seul ou en combinaison avec au moins un autre domaine de TM sélectionné dans le groupe constitué par le domaine de région hydrophobe N-terminale, le domaine EGF123, la boucle interdomaines entre EGF3 et EGF4, et le domaine riche en Ser/Thr O-glycosylé, ou des analogues, des fragments, des dérivés ou des variantes génétiques desdites protéines. La protéine de fusion se lie au site de lésion et empêche le déclenchement d'une thrombose. La protéine de fusion peut servir à traiter diverses affections thrombotiques incluant notamment, mais pas exclusivement, la thrombose veineuse profonde, la coagulation intravasculaire disséminée et le syndrome coronaire aigu.
Light David
Mclean Kirk
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
Schering Aktiengesellschaft
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