Novel toxicity assay based on human blastocyst-derived stem...

Details Novel toxicity assay based on human blastocyst-derived stem... Novel toxicity assay based on human blastocyst-derived stem...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2665183

The invention relates to an in vitro toxicity assay based on human blastocyst-derived stem cells for the detection of toxicity in the human species, which enables novel detection of in vitro human toxicity for a substance and/or more efficiently detects human toxicity compared to non-human assays. The invention can furthermore enable detection of toxicity for substances, which are known to display inter-species differences and the toxic effect was not detectable by toxicological tests in mice.

La présente invention concerne un essai de toxicité in vitro basé sur des cellules souches dérivées de blastocystes humains et destiné à la détection d'une toxicité pour l'espèce humaine. L'essai procure un nouveau mode de détection in vitro de la toxicité d'une substance pour l'homme et/ou il permet la détection plus efficace d'une toxicité pour l'homme, par comparaison aux essais utilisant des éléments non humains. L'invention peut en outre permettre la détection de la toxicité de substances connues pour présenter des différences interespèces et dont l'effet toxique n'était pas détectable au moyen de tests toxicologiques utilisant des souris.

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