C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2084222
This invention relates to novel Trans cyclopentanyl purine analogs of the formula (1) (see formula 1) wherein the substituent in the 3-position on the cyclopentanyl rang is in the Trans configuration relative to the bicyclic substituent, Y3. Y5 Y7, Y8 and Y9 are each independently nitrogen or a CH group, R is a hydrogen, a C1-C7 alkyl acyl or aryl acyl, Q is NH2, halogen or hydrogen, Z is hydrogen, halogen, or NH2; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Borcherding David R.
Cole Douglas L.
Edwards Carl K. III
Esser Ronald E.
Aventisub II Inc.
Marion Merrell Dow Inc.
Osler Hoskin & Harcourt Llp
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