Novel transcription factor and dna thereof

Details Novel transcription factor and dna thereof Novel transcription factor and dna thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61P 19/02 (2006.01) C07K 14/47 (2006.01) C07K 14/51 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2392351

A polypeptide having an activity of binding specifically to the cis-element of ChM-I gene promoter and promoting the transcription of the ChM-I gene. Therefore, the polypeptide and its DNA are useful as preventives/remedies for diseases such as rheumatoid arthritis, arthrosis deformans, osteoporosis, bone fracture and cancer. Also, the above-described polypeptide and DNA or a transformant thereof are usable in screening, for example, a compound promoting or inhibiting the activity of the polypeptide. Compounds promoting the activity of the above polypeptide or the expression of the above DNA are useful as preventives/remedies for diseases such as rheumatoid arthritis, arthrosis deformans, osteoporosis, bone fracture and cancer. Compounds inhibiting the activity of the above polypeptide or the expression of the above DNA are useful as preventives/remedies for diseases such as intervertebral disk hernia, ischiodynia and etopic chondrogenesis.

L'invention concerne un polypeptide présentant une activité de liaison spécifique à l'élément cis d'un promoteur de gène ChM.I et de promotion de la transcription dudit gène. Par conséquent, le polypeptide et son ADN sont utiles comme agents préventifs/thérapeutiques pour les maladies telles que l'arthrite rhumatoïde, les arthrites dégénératives, l'ostéoporose, les fractures osseuses et le cancer. De plus, le polypeptide et l'ADN précités ou son transformant se prêtent au criblage, par exemple un composé de promotion ou d'hinhibiton de l'activité du polypeptide. Les composés favorisant l'activité de ce polypeptide ou l'expression de l'ADN sont utilisés comme agents préventifs/thérapeutiques pour traiter les maladies notamment, l'arthrite rhumatoïde, les arthrites dégénératives, l'ostéoporose, les fractures osseuses et le cancer. Les composés inhibant l'activité dudit polypeptide ou l'expression de l'ADN sont utilisés comme agents préventifs/thérapeutiques pour traiter les maladies telles que l'hernie discale intervertébrale, l'ischiodynie et la chondrogenèse étopique.

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