Novel triazine-based detoxification agents and their use

Details Novel triazine-based detoxification agents and their use Novel triazine-based detoxification agents and their use

B - Operations, Transporting

01

J

B01J 20/32 (2006.01) A61M 1/36 (2006.01) C02F 1/28 (2006.01) C07K 1/22 (2006.01) G01N 33/50 (2006.01) C07D 251/50 (2006.01) C07D 251/54 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2369442

An affinity ligand-matrix conjugate comprises the matrix and, conjugated thereto by the group Z, a ligand having general formula (I) wherein one X is N and the other X is N, CCL or CCn; A1 and A2 are each independently O, S or N- R1 and R1 is H, C1-6alkyl, C1-6 hydroxyalkyl, benzyl or .beta.-phenylethyl; B1 and B2 are each independently an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D1 is H or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; and D2 is a secondary amino, tertiary amino, quaternary ammonium, imadazole, guanidino or amidino group; or B2-D2 is -CHCOOH-(CH2)3-4-NH2; AND p is 0 or 1. Such conjugates are useful for the separation, isolation, purification, characterisation, identification or quantification of an endotoxin.

Selon cette invention, un conjugué matrice-ligand à affinité comprend la matrice et, conjugué à celle-ci par le groupe Z, un ligand ayant la formule générale (I) dans laquelle un X est N et l'autre X est N, CCI ou CCn; A1 et A2 sont chacun indépendamment O, S ou N-R1 et R1 est H, alkyle C1-6, hydroxyalkyle C1-6, benzyle ou .beta.-phényléthyle; B1 et B2 sont chacun indépendamment une liaison hydrocarbonée contenant entre 1 et 10 atomes de carbone; D1 est H ou un amino primaire, un amino secondaire, un amino tertiaire, un ammonium quaternaire, un groupe imidazole, guanidino ou amidino; et D2 est un amino secondaire, un amino tertiaire, un ammonium quaternaire, un groupe imidazole, guanidino ou amidino; ou B2-D2 est -CHCOOH-(CH2)3-4-NH2; et p est 0 ou 1. Ces conjugués sont utiles dans la séparation, l'isolation, la purification, la caractérisation, l'identification la quantification d'une endotoxine.

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