Novel tricyclic compounds for the inhibition of the...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/06 (2006.01) A01N 1/02 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) A61K 38/55 (2006.01) C07D 471/06 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01) C07F 9/6561 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237314

This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.

Cette invention se rapporte à de nouveaux composés tricycliques qui inhibent les enzymes de la famille ICE/ced-3. Elle se rapporte notamment à des compositions pharmaceutiques de tels composés tricycliques, ainsi qu'à l'utilisation de telles compositions s'agissant de traiter des patients atteints de maladies inflammatoires, auto-immunes et neurodégénératives et de prévenir les ischémies.

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