C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01)
Patent
CA 2743257
The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP- ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.
La présente invention concerne un nouveau dérivé tricyclique présentant une activité inhibitrice efficace contre les poly(ADP-ribose)polymérases (PARP), ou ses sels pharmaceutiquement acceptables. L'invention concerne également un procédé de préparation dudit dérivé, et une composition pharmaceutique le contenant. Le dérivé tricyclique de l'invention est utile pour la prévention ou le traitement, par inhibition de l'activité des poly(ADP-ribose)polymérases, de maladies causées par une activité PARP excessive, notamment la douleur neuropathique, les maladies neurodégénératives, les maladies cardiovasculaires, la néphropathie diabétique, les maladies inflammatoires, l'ostéoporose, et le cancer.
Choi Ji-So
Choi Jong-Hee
Chun Kwang-Woo
Joe Bo-Young
Kim Myung-Hwa
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Je Il Pharmaceuticals Co. Ltd.
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