Novel tricyclic hydroxy carboxamides and derivatives thereof...

Details Novel tricyclic hydroxy carboxamides and derivatives thereof... Novel tricyclic hydroxy carboxamides and derivatives thereof...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 15/06 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2443805

This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

Cette invention porte sur de nouveaux carboxamides tricycliques substitués qui agissent comme antagonistes compétitifs du récepteur de l'oxytocine, ainsi que sur leurs procédés de fabrication, sur des compositions pharmaceutiques et sur leurs procédés d'utilisation dans le traitement, l'inhibition, la suppression ou la prévention de l'accouchement prématuré, de la dysménorrhée et de l'endométrite, la suppression de l'accouchement à terme avant délivrance par césarienne, et pour faciliter le transport prénatal vers une installation médicale. Ces composés sont également utiles pour obtenir de meilleurs taux de fécondité, de meilleurs taux de survie et synchroniser les chaleurs chez les animaux d'élevage. Ces composés peuvent aussi être utiles dans la prévention et le traitement des dysfonctionnements du système de l'oxytocine dans le système nerveux central tels que les troubles obsessionnels compulsifs (TOC) et les troubles neuropsychiatriques.

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