Novel tricyclic steroid analogs

Details Novel tricyclic steroid analogs Novel tricyclic steroid analogs

C - Chemistry, Metallurgy

07

C

C07C 49/345 (2006.01) A61K 31/12 (2006.01) A61K 31/13 (2006.01) A61K 31/275 (2006.01) C07C 49/513 (2006.01) C07C 69/00 (2006.01) C07C 69/16 (2006.01) C07C 69/66 (2006.01) C07C 215/42 (2006.01) C07C 255/47 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2085819

07-24(834)A NOVEL TRICYCLIC STEROID ANALOGS Abstract of the Disclosure Novel tricyclic steroid analogs are disclosed which are lH-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: (I) Image (II) Image wherein R1 = H or C1-C4 alkyl or fluoroalkyl; R2 = H or C1-C4 alkyl or fluoroalkyl, in which R1 and R2 can be the same or different; R3 = H or CH3; R4 = H or CH3, in which R3 and R4 can be the same or different; R5 = H; R6 = H; R5,R6 = =O(carbonyl); R7 = H; R8 = a hydrogen bond accepting group. R7,R8 = =O(carbonyl); and R' = an ester group.

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