C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/05 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) C07C 215/08 (2006.01) C07C 217/70 (2006.01) C07C 233/18 (2006.01) C07C 255/03 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2483141
Disclosed herein are trifluoromethylepinephrine compounds having the following structural formula (I) wherein R1-R5 are each independently selected from the group consisting of H, alkyl, alkoxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, acyl, thioacyl, sulfonyl mercapto, alkylthio, carboxy, amino, alkylamino dialkylamino, carbamoyl, arylthio, and heteroarylthio; wherein X, Y, and Z are each independently selected from the group consisting of H or trifluoromethyl with the proviso that at least one of which is trifluoromethyl. Also disclosed are pharmaceutical compositions comprising the trifluoromethylepinephrine compounds and methods of making and using thereof. Novel trifluoroepinephrine intermediates are also disclosed.
L'invention concerne des composés trifluorométhylépinéphrine représentés par la formule structurale (I) dans laquelle R?1¿-R?5¿ représentent, chacun de manière indépendante, un atome d'hydrogène, un groupe alkyle, alcoxyle, aryle, hétéroaryle, cycloalkyle, hétérocycloalkyle, acyle, thioacyle, sulfonyl mercapto, alkylthio, carboxy, amino, alkylamino dialkylamino, carbamoyle, arylthio, ou hétéroarylthio; et X, Y, et Z représentent, chacun de manière indépendante, un atome d'hydrogène ou un groupe trifluorométhyle sous réserve qu'au moins l'un d'eux représente un groupe trifluorométhyle. L'invention concerne aussi des compositions pharmaceutiques contenant les composés trifluorométhylépinéphrine ainsi que des procédés de fabrication et d'utilisation de ces composés. Elle concerne aussi des intermédiaires de trifluoroépinéphrine.
Sim & Mcburney
The Government Of The United States As Represented By The Secretary Of The Army Medical Research And
LandOfFree
Novel trifluoromethylepinephrine compounds and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel trifluoromethylepinephrine compounds and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel trifluoromethylepinephrine compounds and methods of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1575668