C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250124
Nucleic acids encoding TRIO proteins, the TRIO proteins themselves, and active portions thereof as described. In addition, antibodies immunoreactive with TRIO proteins, and preparations of such compositions are provided. Diagnostic and therapeutic assays and reagents for detecting and treating disorders involving, for example, aberrant expression (or loss thereof) of the TRIO protein are described. Assays are provided for identifying agents that modulate the biological function of TRIO proteins.
L'invention concerne des acides nucléiques codant pour les protéines dites "TRIO", ces protéines TRIO elles-mêmes et des portions actives de celles-ci. L'invention concerne, également, des anticorps capables d'une réaction immunologique avec les protéines TRIO, et des préparations de telles compositions. On décrit des dosages diagnostiques et thérapeutiques pour détecter et traiter des troubles associés, par exemple, à une expression aberrante de la protéine TRIO (ou à la perte de cette expression), ainsi que des méthodes analytiques permettant d'identifier des agents qui modulent les fonctions biologiques des protéines TRIO.
Debant Anne
Serra-Pages Carles
Streuli Michel
Dana-Farber Cancer Institute
Gowling Lafleur Henderson Llp
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