Novel tripeptide compounds and anti-aids drugs

Details Novel tripeptide compounds and anti-aids drugs Novel tripeptide compounds and anti-aids drugs

C - Chemistry, Metallurgy

07

D

C07D 277/06 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 38/06 (2006.01) C07D 211/60 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 263/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/02 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2249747

Novel tripeptide compounds having excellent HIV protease inhibitory activites and represented by general formula (I), pharmacologically acceptable salts thereof, and anti-AIDS drugs containing the same as the active ingredient. An example of the compounds is (R)-N-(2-methylbenzyl)-3-{(2S, 3S)-3-[N-(2- chromonecarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutanoyl}-5, 5- dimethyl-1, 3-thiazolidine-4-carboxamide.

Nouveaux composés de tripeptides présentant une efficacité excellente d'inhibition de la protéase de VIH et représentés par la formule (I), leurs sels acceptables sur le plan pharmacologique et médicaments anti-sida les contenant en tant qu'ingrédient actif. Un exemple de ces composés consiste en (R)-N-(2-méthylbenzyle)-3-{(2S, 3S)-3-[N(-2-chromonecarbonyle)-L-asparaginyle]amino-2-hydroxy-4-phénylbutanoyle}-5, 5-diméthyle-1, 3-thiazolidine-4-carboxamide.

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