Novel trisubstituted pyridine compounds

Details Novel trisubstituted pyridine compounds Novel trisubstituted pyridine compounds

C - Chemistry, Metallurgy

07

D

C07D 213/04 (2006.01) A61K 31/44 (2006.01) A61P 5/48 (2006.01) A61P 17/06 (2006.01) A61P 19/08 (2006.01) A61P 25/28 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 401/10 (2006.01)

Patent

CA 2385210

The present invention relates to a selective inhibitor of mammalian osteoclast cell activity, processes for its preparation and pharmaceutical compositions comprising the same as well as methods of treatment, where said selective inhibitor is administered to a human or animal patient. Said selective inhibitor has been found to inhibit vacuolar H+-ATPase, such as vacuolar H+- ATPase in osteoclast cells, whereby it is therapeutically efficient against physiological disorders involving bone resorption. In an embodiment of the present invention, said selective inhibitor comprises a trisubstituted pyridine compounds with general formula (I).

L'invention concerne un inhibiteur sélectif de l'activité cellulaire des ostéoclastes chez le mammifère, des procédés permettant de préparer cet inhibiteur et des compositions pharmaceutiques comprenant ce dernier, ainsi que des traitements comprenant l'administration de cet inhibiteur sélectif à un patient humain ou animal. On a découvert que cet inhibiteur sélectif inhibe la H?+¿-ATPase vacuolaire, notamment la H?+¿-ATPase vacuolaire des ostéoclastes, présentant ainsi une efficacité thérapeutique contre les troubles physiologiques s'accompagnant d'une résorption osseuse. Dans une forme de réalisation, cet inhibiteur sélectif comprend un composé pyridine trisubstitué représenté par la formule générale (I).

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