Novel type leptin receptor antagonist

Details Novel type leptin receptor antagonist Novel type leptin receptor antagonist

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2585549

The invention relates to a new type of leptin receptor antagonist, which is able to prevent leptin signaling without preventing the binding of leptin to the leptin binding domain. More specifically, the invention relates to the use of a part of the leptin receptor to prevent the leptin- dependent activation of the receptor, and by this the leptin induced signaling.

L'invention concerne un nouveau type d'antagoniste de récepteurs de leptine, permettant d'éviter une signalisation de leptine, sans empêcher la liaison de la leptine au domaine de liaison de la leptine. En particulier, l'invention concerne l'utilisation d'une partie du récepteur de la leptine pour empêcher l'activation leptine-dépendante du récepteur, et ainsi pour empêcher la signalisation induite par la leptine.

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