C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2170384
Disclosed are a novel cytoplasmic tyrosine kinase which is increased with respect to expression amount thereof in accordance with the differentiation of blood cells, and a deoxyribonucleic acid (DNA) coding for the same. The tyrosine kinase of the present invention can be advantageously used for screening chemical substances having the capability to inhibit or activate the tyrosine kinase activity of at least the tyrosine kinase of the present invention. Also disclosed are a replicable recombinant DNA molecule comprising a replicable expression vector and, operably inserted in the vector, a DNA coding for the tyrosine kinase of the present invention; a microorganism or animal cells transformed with the replicable recombinant DNA molecule; and an antibody capable of specifically recognizing the tyrosine kinase of the present invention.
L'invention concerne une nouvelle tyrosine kinase cytoplasmique qui est améliorée quant à son expression selon la différenciation des cellules sanguines. L'invention concerne également l'ADN codant cette nouvelle tyrosine kinase cytoplasmique. Cette kinase est utilisable pour le criblage de substances chimiques qui ont pour effet au moins d'inhiber ou d'activer son activité. L'invention porte également sur les éléments suivants: un ADN réplicable recombiné obtenu en intégrant par réplication l'ADN ci-dessus dans un vecteur d'expression réplicable; un micro-organisme ou une cellule animale transformé(e) par l'ADN recombiné; un anticorps obtenu par utilisation d'une partie de la séquence d'acides aminés de la tyrosine kinase servant d'immunogène; un ADN sens et un ADN antisens préparés en utilisant l'ADNc de la tyrosine kinase; un ARN sens et un ARN antisens.
Asahi Kasei Kogyo Kabushiki Kaisha
Goudreau Gage Dubuc
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