C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 9/88 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2341064
The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host cell expression systems and proteins encoded by the nucleotides of the present invention. The present invention relates to screening assays that use the novel substrate-targeting subunits to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel ubiquitin ligases which modulate activity of the novel ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative disorders.
La présente invention concerne la découverte, l'identification et la caractérisation de nucléotides codant pour de nouvelles sous-unités d'ubiquitine ligases ciblant un substrat. L'invention concerne des nucléotides codant pour de nouvelles sous-unités d'ubiquitine ligases ciblant un substrat: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24 et FBP25, des souris transgéniques, des souris <= knock-out >=, des systèmes d'expression cellulaires hôtes et des protéines codées par les nucléotides de l'invention. L'invention a trait à des techniques de criblage utilisant les nouvelles sous-unités ciblant un substrat pour identifier des agents thérapeutiques potentiels tels que de petites molécules, des composés ou dérivés, et des analogues des nouvelles ubiquitine ligases qui modulent l'activité des nouvelles ubiquitine ligases, en vue de traiter des troubles de prolifération et de différenciation cellulaires tels que le cancer, des infections opportunistes majeures, des troubles immunitaires, certaines maladies cardio-vasculaires et des maladies inflammatoires. L'invention concerne de plus des protocoles thérapeutiques et des compositions pharmaceutiques conçues pour cibler des ubiquitine ligases et leurs substrats, en vue du traitement de troubles de prolifération cellulaire.
Chiaur Dah Shiarn
Latres Esther
Pagano Michele
New York University
Osler Hoskin & Harcourt Llp
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