Novel urea and thiourea derivatives

Details Novel urea and thiourea derivatives Novel urea and thiourea derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/40 (2006.01) A61K 31/4409 (2006.01) A61K 31/4427 (2006.01) C07D 213/75 (2006.01) C07D 231/40 (2006.01) C07D 239/42 (2006.01) C07D 253/07 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2735373

The present application discloses compounds of formula (I) wherein X is =O, =S, =NH, =NOH and =NO-Me; A is -C(=O)-, -S(=O)2 -, -C(=S)- and P(=O)(R5)-; B is, -O-, -(CH2)3-6-, and O- (CH2)2-5-; D is, -O-, -CR7R8 -and -NR9; m is 0-12, n is 0-12, m+n is 1-20; p is 0-4; R1 is opt heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The application also discloses the compound for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT), e.g. inflammatory and tissue repair disorders; dermatosis; autoimmune diseases, Alzheimers disease, stroke, athersclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and certain viral infections, including Acquired Immune Deficiency Syndrome (AIDS), adult respiratory distress syndrome, ataxia telengiectasia.

La présente invention concerne des composés de formule dans laquelle X est =O, =S, =NH, =NOH et =NO-Me; A est -C(=O)-, -S(=O)2-, -C(=S)- et P(=O)(R5)-; B est -O-, -(CH2)3-6-, et O-(CH2)2-5-; D est -O-, -CR7R8- et -NR9; m est 0 à 12, n est 0 à 12, m+n est 1 à 20; p est 0 à 4; R1 est un hétéroaryle facultativement substitué; et des sels pharmaceutiquement acceptables de ceux-ci, et des promédicaments de ceux-ci. La présente invention concerne en outre le composé pour utilisation en tant que médicament pour le traitement dune maladie ou dune affection causée par un taux élevé de nicotinamide phosphoribosyltransférase (NAMPRT), par exemple des troubles inflammatoires et de réparation de tissu; la dermatose; des maladies auto-immunes, la maladie dAlzheimer, un accident cérébrovasculaire, lathérosclérose, une resténose, le diabète, la glomérulonéphrite, le cancer, la cachexie, une inflammation associée à une infection et certaines infections virales, comprenant le syndrome dimmunodéficience acquise (SIDA), le syndrome de détresse respiratoire de ladulte, lataxie télangiectasie.

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