C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/34 (2006.01) A61K 31/17 (2006.01) A61P 25/00 (2006.01) C07C 275/30 (2006.01) C07C 275/40 (2006.01)
Patent
CA 2561639
This invention relates to novel urea derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
La présente invention a trait à de nouveaux dérivés d'urée, qui sont des modulateurs des récepteurs nicotiniques de l'acétylcholine. Grâce à leur profil pharmaceutique, les composés de l'invention peuvent être utiles pour le traitement de maladies ou de troubles aussi divers que ceux liés au système cholinergique du système nerveux central, du système nerveux périphérique, de maladies ou troubles associés à la contraction des muscles lisses, de maladies ou troubles endocriniens, de maladies ou troubles associés à la neurodégénérescence, de maladies ou troubles liés à l'inflammation, la douleur et aux symptômes de sevrage provoqués par la cessation d'abus de substances chimiques.
Dahl Bjarne H.
Dyhring Joergensen Tino
Olsen Gunnar M.
Peters Dan
Timmermann Daniel B.
Mccarthy Tetrault Llp
Neurosearch A/s
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