Novel use of antibodies as vaccines

Details Novel use of antibodies as vaccines Novel use of antibodies as vaccines

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) C07K 1/22 (2006.01) C07K 16/06 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2391927

The invention relates to the use of antibodies, which bind to antibodies for tumour-associated antigens and which are obtained from individual body fluids by immuno-affinity purification with specific ligands, for the production of individual, autologous, prophylactic or therapeutic vaccination against cancerous disease states. The ligands for immuno-affinity purification are antibodies or derivatives thereof, to tumour associated antigens. The invention further relates to pharmaceutical compositions, which comprise the antibodies produced by immuno-affinity purification, or the dendritic cells pulsed in-vitro by said antibodies.

L'invention concerne l'utilisation d'anticorps se liant à des anticorps contre des antigènes tumoraux, et obtenus à partir de fluides corporels par purification par affinité immunologique de liants spécifiques, pour la fabrication d'une composition de vaccination individuelle, autologue, prophylactique ou thérapeutique contre des maladies cancéreuses. Les liants de la purification par affinité immunologique sont des anticorps ou des dérivés de ceux-ci, dont l'activité est orientée contre des antigènes tumoraux. L'invention concerne par ailleurs des compositions pharmaceutiques contenant les anticorps obtenus par purification par affinité immunologique ou des cellules dendritiques pulsées in vitro avec ces anticorps.

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