Novel use of arylethene sulfonamide derivatives

Details Novel use of arylethene sulfonamide derivatives Novel use of arylethene sulfonamide derivatives

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07D 239/47 (2006.01)

Patent

CA 2443042

Novel use of N-[6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4- yl]-2-phenylethene sulfonamide or its pharmaceutically acceptable salt, i.e., amelioration in the following specific syndromes of patients with diabetes: (1) an increase in blood glucose level; (2) an increase in blood lipid level following the occurrence of early nephropathy; (3) renal functional disorder following the occurrence of early nephropathy; (4) an increase in urinary albumin discharge following the occurrence of early nephropathy; (5) glomerular overfiltration following the occurrence of early nephropathy; (6) renal functional disorder following the transition into chronic renal insufficiency; and (7) an increase in urinary protein discharge following the transition into chronic renal insufficiency.

L'invention se rapporte à une nouvelle utilisation de N-[6-méthoxy-5- (2-méthoxyphénoxy) -2-(pyrimidine-2-yl) pyrimidine-4-yl] 2-phényléthène sulfonamide ou à ses sels pharmaceutiquement acceptables, c'est-à-dire, à l'amélioration des syndromes spécifiques suivants chez des patients atteints de diabète : (1) augmentation du taux de glycémie dans le sang ; (2) augmentation du taux de lipides dans le sang suite à l'apparition récente d'une néphropathie ; (3) trouble du fonctionnement rénal suite à l'apparition récente d'une néphropathie récente ; (4) augmentation de la perte en albumine dans l'urine suite à l'apparition récente d'une néphropathie ; (5) surfiltration glomérulaire suite à l'apparition récente d'une néphropathie ; (6) dysfonctionnement rénal suite à une insuffisance rénale chronique ; et (7) augmentation de la perte en protéines dans l'urine suite à une insuffisance rénale chronique.

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