Novel use of benzothiazole derivatives

Details Novel use of benzothiazole derivatives Novel use of benzothiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/62 (2006.01) A61K 31/428 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/5377 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07D 277/66 (2006.01) C07D 417/02 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2495492

The use of compounds of formula (I) wherein X, A, B, D, R1 and R2 are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

L'invention concerne l'utilisation de composés de la formule (I), dans laquelle X, A, B, D, R?1¿ et R?2¿ sont tels que définis dans la spécification, et de leurs sels pharmaceutiquement acceptables dans la fabrication d'un médicament destiné au traitement ou à la prophylaxie de maladies ou d'états dans lesquels l'inhibition de l'activité de kinase Itk est bénéfique. L'invention concerne également certains nouveaux composés de la formule (I), ainsi que leurs procédés de préparation, les compositions les renfermant et leur utilisation en thérapie.

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