A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/496 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2429216
The present invention relates to the use of compounds being combined selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT1A receptor agonists, in particular of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)- piperazine or a physiologically acceptable salt thereof or 3-{4-[4-(4-cyano- phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile or a physiologically acceptable salt thereof, for the manufacture of a medicament for the treatment of chronic pain disorders or in treating other conditions where there is hyper- sensitization to painful signals, hyperalgesia, allodynia, enhanced pain perception, and enhanced memory of pain, as well as for the treatment of irritable bowel syndrome (IBS).
La présente invention concerne l'utilisation de composés, tels que des combinaisons d'inhibiteurs sélectifs du recaptage de la sérotonine (5-HT) (SSRI) et d'agonistes du récepteur 5-HT¿1A?, en particulier 1-[4(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofurane-5-yl)-piperazine, ou un sel pharmaceutiquement acceptable de celui-ci, ou 3-{4-[4-cyano-phenyl)-piperazine-1-yl]-butyl}-1H-indole-5-carbonitrile, ou un sel pharmaceutiquement acceptable de celui-ci, pour la fabrication d'un médicament destiné au traitement des douleurs chroniques ou pour le traitement d'autres affections caractérisées par une hyper-sensibilisation aux signaux de douleur, l'hyperalgie, l'allodynie, de l'atténuation de la perception de la douleur, de l'atténuation du souvenir de la douleur, ainsi que pour le traitement du syndrome du côlon irritable.
Bartoszyk Gerd
Sedman Ewen
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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