Novel use of liver x receptor agonists

Details Novel use of liver x receptor agonists Novel use of liver x receptor agonists

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2608052

The present invention generally relates to a novel therapeutical use of liver X receptor (LXR) agonsits. More specifically, the present invention relates to the use of LXR agonist for the preparation of a medicament useful for the treatment and/or the prevention of a disease associated with beta cells degeneration, such as diabetes, and a method for increasing ex vivo viability of pancreatic islet cells, comprising contacting said islet cells with a LXR agonist.

Cette invention concerne de façon générale une nouvelle utilisation thérapeutique des agonistes du récepteur X du foie (LXR). Plus spécifiquement, cette invention concerne l'utilisation d'un agoniste du récepteur LXR pour la préparation d'un médicament servant au traitement et/ou à la prévention des maladies associées à la dégénérescence des cellules bêta, telles que le diabète, ainsi qu'un procédé permettant d'accroître la viabilité ex vivo des cellules dites îlots de Langerhans et consistant à mettre ces cellules en contact avec un agoniste de LXR.

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