Novel use of phenylheteroalkylamine derivatives

Details Novel use of phenylheteroalkylamine derivatives Novel use of phenylheteroalkylamine derivatives

C - Chemistry, Metallurgy

07

C

C07C 255/58 (2006.01) A61K 31/137 (2006.01) A61K 31/277 (2006.01) A61K 31/421 (2006.01) A61K 31/5375 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07C 211/53 (2006.01) C07C 323/32 (2006.01) C07D 263/32 (2006.01) C07D 295/125 (2006.01)

Patent

CA 2396960

There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prohylaxis of inflammatory disease.

L'invention concerne l'utilisation d'un composé de la formule (I) où R?1¿, R?2¿, X, Y, V, W et Z ont la définition donnée dans la description ; de ses sels pharmaceutiquement acceptables, de ses énantiomères ou racémates dans la production d'un médicament destiné au traitement ou à la prévention de maladies ou d'états dans lesquels l'inhibition de l'activité de la synthétase d'oxyde nitrique est bénéfique. L'invention concerne également certains nouveaux composés de la formule (Ia), leurs sels pharmaceutiquement acceptables, et leurs énantiomères et racémates ainsi que leurs procédés de préparation, les compositions les contenant et leur utilisation en thérapie. Les composés de la formule (I) et (Ia) sont inhibiteurs de l'enzyme synthétase d'oxyde nitrique et sont donc particulièrement utiles dans le traitement ou la prévention de maladies inflammatoires.

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