Novel uses for thyroid hormones or thyroid hormone-like...

A - Human Necessities – 61 – K

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Details

A61K 38/00 (2006.01) A61K 38/06 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2415285

The present invention is directed to the sue of at least one thyroid hormone compound or thyroid hormone-like agonist compound in the preparation of a topical medicament for the treatment of a dermatological condition affecting the dermis. The thyroid hormone compound or the thyroid hormone-like agonist compound binds to TR-.alpha. or TR-.beta. with an equilibrium dissociation constant, Kd, of less than 5 x 10-6 M. The invention is also directed to a composition for treating a dermatological conditions affecting the dermis and to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating such a condition. Use of at least one thyroid hormone or thyroid hormone-like agonist compound in the preparation of a topical medicament for the pre-treatment of skin in dermatological surgery is also provided.

L'invention concerne l'utilisation d'au moins un composé d'hormone de la thyroïde ou un composé agoniste semblable à l'hormone de la thyroïde dans la préparation d'un médicament topique destiné au traitement d'une affection dermatologique affectant le derme. Le composé d'hormone de la thyroïde ou le composé agoniste semblable à l'hormone de la thyroïde se lie à TR-.alpha. ou TR-.beta. avec une constante de dissociation d'équilibre, K¿d?, inférieure à 5 x 10?-6¿ M. L'invention concerne également une composition destinée au traitement d'une affection dermatologique affectant le derme, un article de fabrication comprenant du matériel d'emballage et un agent pharmaceutique contenu dans le matériel d'emballage, cet agent étant efficace sur le plan thérapeutique pour traiter une telle affection. L'invention concerne enfin l'utilisation d'au moins une hormone de la thyroïde ou un composé agoniste semblable à l'hormone de la thyroïde dans la préparation d'un médicament topique destiné au traitement préalable de la peau dans la chirurgie dermatologique.

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