Novel uses of antibodies against ache and peptides thereof

Details Novel uses of antibodies against ache and peptides thereof Novel uses of antibodies against ache and peptides thereof

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2371675

The invention relates to antibodies recognizing acetylcholinesterase or a C- terminal peptide derived from acetylcholinesterase, useful in diagnosing central nervous system (CNS) stress, elevated glucocorticoid level, disruption of the blood-brain barrier or Alzheimer's disease. The invention also relates to methods for the diagnosis of central nervous system (CNS) stress, elevated glucocorticoid level or disruption of the blood-brain barrier in a mammal, by use of the antibodies of the invention.

L'invention concerne des anticorps reconnaissant l'acétylcholinestérase ou un peptide C-terminal dérivé de l'acétylcholinestérase, utiles dans le diagnostic du stress du système nerveux central (SNC), de niveaux élevés de glucocorticoïdes, d'un dérèglement de la barrière hémato-encéphalique ou de la maladie d'Alzheimer. L'invention concerne également des techniques de diagnostic du stress du système nerveux central (SNC), de niveaux élevés de glucocorticoïdes ou d'un dérèglement de la barrière hémato-encéphalique chez un mammifère, utilisant les anticorps de l'invention.

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