Novel vaccines against multiple subtypes of dengue virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C07K 14/08 (2006.01) C12N 15/54 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2708668

An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.

La présente invention concerne par l'un de ses aspects, d'une part une construction d'acide nucléique capable d'exprimer un polypeptide suscitant chez un mammifère une réponse immunitaire contre un ou plusieurs sous-types de virus de la dengue, et d'autre part des procédés d'utilisation correspondants. L'invention concerne en outre, d'une part des vaccins à plasmides d'ADN, qui sont capables de générer chez un mammifère une réponse immunitaire contre une pluralité de sous-types du virus de la dengue, et qui comprennent un plasmide d'ADN et un excipient pharmaceutiquement admis, et d'autre part des procédés d'utilisation correspondants. Ce plasmide d'ADN est capable d'exprimer dans une cellule du mammifère un antigène de consensus contre la dengue, en quantité suffisante pour susciter chez le mammifère une réponse immunitaire.

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