C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2452260
The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders such as neurological and psychiatric disorders including schizophrenia. The invention also provides antibodies directed specifically against these novel polypeptides, and kits comprising the herein-described polynucleotides, polypeptides, and/or antibodies.
L'invention concerne des séquences polypeptidiques et polynucléotidiques pour de nouveaux variants d'épissage du transporteur type 1 de glycine (GlyT1) dépendant du sodium et du chlore. Ces polypeptides et polynucléotides sont utilisés dans le traitement et le diagnostic de troubles tels que des troubles neurologiques et psychiatriques, y compris les schizophrénies. L'invention concerne également des anticorps dirigés spécifiquement contre ces nouveaux polypeptides, ainsi que des kits comprenant les polynucléotides, polypeptides et/ou anticorps précités.
Grel Pascale
Jais Philippe
Mace Sandrine
Thill Gilbert
Genset S.a.
Kirby Eades Gale Baker
Serono Genetics Institute S.a.
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