Novel viii factors for the treatment of type a hemophilia

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/755 (2006.01) A61K 38/37 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2678190

The present invention relates to improved variants of the human FVIII having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their use 5 in the treatment of type A hemophilia, particularly in patients with inhibitors.

La présente invention est relative à des variants améliorés du FVIII humain présentant au moins une substitution dans le domaine A2 et/ou C2. La présente invention est également relative à leurs utilisations 5 pour le traitement de l'hémophilie de type A, notamment chez des patients à inhibiteurs.

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