C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/04 (2006.01) A61K 31/675 (2006.01) A61K 31/706 (2006.01) A61K 45/00 (2006.01) A61P 31/12 (2006.01) C07F 9/6558 (2006.01) C12N 9/99 (2006.01) C07H 19/10 (2006.01)
Patent
CA 2456292
(I) In the formulae, R1, R2, R3, R4, R5, R6, R7, R8, R9, and A have the same meanings as in the description. A method in which pyradine nucleotide and pyradine nucleoside analogues [2] and [3z] undergo in vivo conversion and are further decomposed and phosphorylated to become a pyradine nucleotide analogue [1b], which has virus proliferation inhibitory activity and/or virucidal activity. The method is useful as a remedy for viral infectious diseases. Also provided is a pyradinecarboxamide analogue or a salt thereof which are useful as a preventive/remedy for viral infectious diseases.
Dans les formules de l'invention, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et A sont tels que définis dans la description. L'invention concerne une méthode selon laquelle des analogues de pyradine nucléotide et de pyradine nucléoside (2 et 3z) subissent une conversion in vivo, puis une décomposition et une phosphorylation, d'où l'obtention d'un analogue de pyradine nucléotide (1b) présentant une activité inhibitrice de la prolifération virale et/ou une activité virocide. Cette méthode est utile pour traiter les maladies infectieuses virales. L'invention concerne également un analogue de pyradinecarboxamide ou un sel dudit composé utile comme agent prophylactique/thérapeutique destiné aux maladies infectieuses virales.
Egawa Hiroyuki
Furuta Yousuke
Murakami Makoto
Takahashi Kazumi
Tsutsui Yasuhiro
Marks & Clerk
Toyama Chemical Co. Ltd.
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