Novel vitamin d analogues

Details Novel vitamin d analogues Novel vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61K 31/695 (2006.01) C07D 309/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2136451

2136451 9407851 PCTABS00032 The invention relates to compound of formula (I) in which formula R stands for a straight or branched, saturated or unsaturated alkyl group containing from 4 to 12 carbon atoms optionally substituted with a hydroxy group, and possibly containing a ring structure, and in which at least one of the carbon atoms not bearing a hydroxyl group is substituted with one or more halogen atoms or an azido group; and prodrugs of (I) in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo, in pure form or in mixtures. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.

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