Novel vitamin d analogues

Details Novel vitamin d analogues Novel vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2140247

Novel trienes have been provided which have antiinflammatory and immunomodulating effects. Such trienes have the Formula I (See Figure I) in which formula Q is -CH2-, -CH=CH- or -C .ident. C-; U is a C1-C6 alkylene; R1 is hydrogen, a C1-C4 alkyl or YR', in which Y stands for the radicals -SO- or -SO2-, and R' stands for a C1-C4 alkyl; R2 and R3 are independently hydrogen or C1-C4 alkyl, and additionally R2 and R3, when taken together with the starred carbon atom, may form a C3-C6 carbocyclic ring; Z is hydrogen or hydroxy; and prodrugs of the compound of Formula I in which at least one of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo.

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