Novel vitamin d analogues

Details Novel vitamin d analogues Novel vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07F 9/117 (2006.01) C07H 15/207 (2006.01)

Patent

CA 2073983

Novel compounds of the following Formula I are provided herein. Image in which Formula: X is hydrogen or hydroxy; Y is oxygen, sulphur, S(O) or S(O)2; R1 and R2, which may be the same or different stand for hydrogen or C1-C6 hydrocarbyl; or R1 and R2, taken together with the carbon atom, starred in Formula I, bearing the group X, can form a C3-C8 carbocyclic ring; Q is an unsubstituted C1-C8 hydrocarbylene diradical, or is a C1-C8 hydrocarbylene diradical which is substituted with at least one fluorine atom, R3 is hydrogen, methyl or ethyl; n is 0 or 1; and derivatives of the compounds of Formula I in which at least one hydroxy group has been transformed into a masked group comprising -O-acyl or -O-glycosyl, or a phosphate ester, such masked groups being hydrolysable in vivo. Processes for preparing such compounds are also provided, as well as pharmaceutical composition containing such compounds and various treatment and prophylactic uses. These compounds show antiinflammatory and immunomodulating effects as well as a strong activity in inducing cell differentiation and inhibiting undesirable proliferation of certain cancer and skin cells.

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