C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/04 (2006.01) A61K 31/7042 (2006.01) C07H 17/00 (2006.01) C07H 17/02 (2006.01) C07H 19/02 (2006.01) C07H 19/22 (2006.01)
Patent
CA 2585091
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
L'invention concerne de nouveaux analogues et dérivés de novobiocine, notamment des composés présentant des modifications dans la chaîne latérale d'amide, le cycle coumarine et des fractions de sucre. Les composés de la présente invention sont utiles en tant qu'inhibiteurs de la protéine 90 du choc thermique et ils peuvent être utilisés comme agents anticancéreux et neuroprotecteurs.
Blagg Brian S.
Neckers Len
Yu Xiao Ming
Smart & Biggar
The Government Of The United States Of America As Represented By
University Of Kansas
LandOfFree
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