G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) C12Q 1/60 (2006.01) G01N 33/532 (2006.01) G01N 33/534 (2006.01)
Patent
CA 2553769
The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPClL1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.
La présente invention concerne des polypeptides NPCIL1 humains, de rat et de souris, et des polynucléotides codant pour ces polypeptides. L'invention a également pour objet des procédés pour détecter des ligands qui se lient à NPClL1 et bloquent l'absorption intestinale du cholestérol. L'invention concerne aussi un procédé pour identifier des ligands qui se lient à NPCILI au moyen de membranes dérivées de préparations de membranes à bordure en brosse. Les composés qui se lient à NPCILI peuvent être utilisés pour inhiber l'absorption intestinale du cholestérol chez une personne.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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