Npy antagonists: spiroisoquinolinone derivatives

Details Npy antagonists: spiroisoquinolinone derivatives Npy antagonists: spiroisoquinolinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/438 (2006.01)

Patent

CA 2381111

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of spiroisoquinolinone derivatives of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

L'invention concerne une série d'antagonistes non peptidergiques des neuropeptides Y (NPY) synthétisés et comprenant des dérivés de spiroisoquinolinone de formule (I). En tant qu'antagonistes de comportement alimentaire induit par les neuropeptides Y, on peut s'attendre que ces composés et les produits analogues agissent comme des agents anorexigènes efficaces en favorisant la perte de poids et le traitement des troubles alimentaires.

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