A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2328992
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of Nr-CAM in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for Nr-CAM. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of Nr-CAM gene expression or the inhibition of -CAM activity in transformed cells reverses the transformed phenotype.
L'invention concerne l'identification d'un nouveau rôle de Nr-CAM dans une transformation cellulaire et une prolifération cellulaire aberrante. L'invention concerne, en particulier, l'expression génique altérée de Nr-CAM dans un certain nombre de tumeurs primaires et de lignées cellulaires dérivées de ces tumeurs, ainsi que l'expression génique altérée de ligands pour Nr-CAM. L'invention est basée, en partie, sur la découverte étonnante par le déposant, du fait que l'inhibition de l'expression génique de Nr-CAM ou l'inhibition de l'activité de Nr-CAM dans des cellules transformées inverse le phénotype transformé.
Boynton Alton L.
Murphy Gerald P.
Sehgal Anil
Fetherstonhaugh & Co.
Northwest Hospital
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