Nsaid formulation comprising a granular composition and an...

Details Nsaid formulation comprising a granular composition and an... Nsaid formulation comprising a granular composition and an...

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2449352

A formulation comprising a granular composition and an extra-granular composition. The granular composition comprises a plurality of solidified melt granules comprising a continuous phase of a non-steroidal anti-inflammatory drug (NSAID). The extra-granular composition comprises a wicking agent which is insoluble in water and comprises at least one of an inorganic material, stearic acid or an insoluble salt thereof, a starch material, a cellulose material or a mixture thereof. The formulation does not contain silicon dioxide.

L'invention concerne une préparation renfermant une composition granulaire et une composition extra-granulaire. La composition granulaire comprend une pluralité de granules solidifiés obtenus par fusion, renfermant une phase continue à base d'un anti-inflammatoire non stéroïdien (AINS). La composition extra-granulaire renferme un agent d'enrobage insoluble dans l'eau et au moins un des éléments du groupe comprenant une matière inorganique, de l'acide stéarique ou un de ses sels insolubles, une matière à base d'amidon, une matière à base de cellulose ou un mélange de ces matières. La préparation ne renferme pas de silice.

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