Nt-3 and bdnf analogs having improved circulating life...

Details Nt-3 and bdnf analogs having improved circulating life... Nt-3 and bdnf analogs having improved circulating life...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/50 (2006.01) C07K 14/54 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2259163

The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.

Selon la présente invention, on accroît la durée de vie en circulation in vivo et/ou l'absorption de protéines thérapeutiques cationiques, et entre autres des protéines basiques telles que les facteurs NT-3 et BDNF, en générant des analogues qui possèdent un point isoélectrique plus faible et de préférence, également une charge protéique plus faible que la protéine de la séquence native.

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