C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2454185
The present invention relates to a novel protein, termed NTB-A, nucleic acid molecules encoding the same and uses thereof. The invention also relates to methods of regulating Natural Killer cells activity by regulating the activity of NTBA-A in vitro, ex vivo or in vivo. The invention also comprises methods of screening active compounds using NTB-A or fragments thereof, or nucleic acid encoding the same, or recombinant host cells expressing said polypeptide.
La présente invention concerne une nouvelle protéine, appelée NTB-A, des molécules d'acide nucléique codant pour celle-ci, ainsi que leurs utilisations. L'invention a également pour objet des procédés destinés à réguler l'activité des cellules tueuses naturelles par régulation de l'activité de la NTB-A in vitro, ex vivo ou in vivo. Cette invention concerne également des procédés destinés au criblage de composés actifs au moyen de NTB-A ou de fragments de celle-ci, ou d'acide nucléique codant pour celle-ci, ou encore de cellules hôtes recombinées exprimant ledit polypeptide.
Biassoni Roberto
Bottino Cristina
Moretta Alessandro
Innate Pharma
Robic
Universita Di Genova
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