C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2542629
Haplotypes in the NTRK1 gene associated with age of onset of Alzheimer~s Disease are disclosed. Compositions and methods for detecting and using these NTRK1 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these NTRK1 haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.
L'invention concerne des haplotypes dans le gène NTRK1 associés à l'apparition de la maladie d'Alzheimer. L'invention concerne également des compositions et des procédés pour détecter et utiliser les haplotypes de NTRK1 dans une pluralité d'applications cliniques. Lesdites applications comprennent des articles de fabrication comprenant des composés efficaces dans le retardement de l'apparition de la maladie d'Alzheimer chez un individu à risques et présentant un des haplotypes de NTRK1, des procédés et des kits pour prévenir l'apparition de la maladie d'Alzheimer chez un individu à risques sur la base de son profil d'haplotypes, et des procédés pour retarder l'apparition de la maladie d'Alzheimer chez un individu à risque sur la base de son profil d'haplotypes.
Aerssens Jeroen
Athanasiou Maria
Brain Carlos
Cohen Nadine
Dain Bradley
Genaissance Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
Pgxhealth Llc
LandOfFree
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