Nuclear protein serine/threonine kinases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2208237

The current invention describes the identification of a novel widely-expressed human and D. melanogasterserine/threonine protein kinase (designated nuclear, Dbf2-related kinase, or Ndr; previously referred to as Ndr) and the use of this kinase for the identification of agonists and antagonists. The kinase is a nuclear protein and contains a short basic peptide, KRKAETWKRNRR, responsible for the nuclear accumulation.

La présente invention concerne l'identification d'une protéine kinase largement exprimée, en l'occurrence une protéine sérine/thréonine kinase d'origine humaine mais provenant également du D. melanogaster. Ces kinases baptisées "Ndr" pour kinase nucléaire apparentée à Dbf2 recevaient jusqu'alors la dénomination de kinases Pun. L'invention concerne également l'utilisation de ces kinases pour l'identification d'agonistes et d'antagonistes. Ces kinases sont une protéine nucléaire contenant un peptide basique court, KRKAERWKRNRR, responsable de l'accumulation nucléaire.

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