C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2469356
An isolated Shoca polypeptide comprising: (i) the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a variant thereof which is capable of interacting with a polypeptide of the wnt signalling pathway; or (iii) a fragment of (i) or (ii) which is capable of interacting with a polypeptide of the wnt signalling pathway, a polypeptide encoding said polypeptide, a method for identifying a modulator of the wnt signalling pathway utilising said polypeptide or polynucleotide and methods of diagnosing and treating cancer.
La présente invention concerne un polypeptide Shoca isolé comprenant: (i) la séquence d'acides aminés SEQ ID NO: 2 ou SEQ ID NO: 4; ou (ii) un variante de celle-ci qui est capable d'interagir avec un polypeptide de la voie de signalisation wnt; ou (iii) un fragment de (i) ou de (ii) qui est capable d'interagir avec un polypeptide de la voie de signalisation wnt. L'invention a également pour objet un polynucléotide codant pour ledit polypeptide, un procédé pour identifier un modulateur de la voie de signalisation wnt au moyen dudit polypeptide ou polynucléotide, et des procédés pour diagnostiquer et traiter le cancer.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Children's Hospital Of Both Cantons Of Basel
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