Nuclear receptor ligands and ligand binding domains

Details Nuclear receptor ligands and ligand binding domains Nuclear receptor ligands and ligand binding domains

C - Chemistry, Metallurgy

07

K

C07K 14/72 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 5/14 (2006.01) C07K 14/47 (2006.01) G01N 33/48 (2006.01) G01N 33/483 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01)

Patent

CA 2240024

The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three-dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as "TR"). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

L'invention concerne des méthodes nouvelles, plus particulièrement des méthodes de calcul et des compositions pour la production de ligands synthétiques de récepteurs nucléaires sur la base de la structure tridimensionnelle de récepteurs nucléaires, en particulier le récepteur des hormones thyroïdiennes (appelé ici TR). Elle porte aussi sur des cristaux, des ligands synthétiques de récepteurs nucléaires et les méthodes associées.

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