Nuclear receptors related to the retinoid receptor x family

Details Nuclear receptors related to the retinoid receptor x family Nuclear receptors related to the retinoid receptor x family

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2177642

Two novel retinoic acid receptors are disclosed. These two receptors are members of the retinoic X receptor (RXR) family of nuclear receptors. These receptors exhibit a high degree of amino acid conservation with other vertebrate RXR's, but contain a conserved sequence which encodes an additional fourteen amino acid segment within their ligand binding domains. These RXR's do not bind 9-cis retinoic acid (RA) or all-trans RA with high affinity and are not activated by 9-cis RA. These RXR's are able to form dimers in a manner equivalent to that of other RXR's.

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