Nuclease resistant double-stranded ribonucleic acid

Details Nuclease resistant double-stranded ribonucleic acid Nuclease resistant double-stranded ribonucleic acid

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A01N 43/04 (2006.01)

Patent

CA 2568013

This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

La présente invention concerne un acide oligoribonucléique double brin modifié (ARNdb) possédant une stabilité accrue dans des cellules et des liquides biologiques, ainsi que des méthodes destinées à la fabrication et à l'identification d'ARNdb possédant une stabilité accrue et à l'utilisation d'ARNdb pour inhiber l'expression ou la fonction d'un gène cible.

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