Nuclease resistant, pyrimidine modified oligonucleotides...

Details Nuclease resistant, pyrimidine modified oligonucleotides... Nuclease resistant, pyrimidine modified oligonucleotides...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 19/10 (2006.01) C07H 19/12 (2006.01)

Patent

CA 2088258

Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides at a plurality of sites, especially at the 3' end of a selected oligonucleotide analog.

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